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Objectives
The aim of this study was to assess associations between loss of control (LOC) eating and health outcomes among adolescents undergoing metabolic and bariatric surgery.
Methods
A total of 234 adolescents were studied before and up to 6 years after surgery in a prospective, observational cohort design. Adolescents provided self‐reports of LOC eating, pain severity, sleep quality, polycystic...
Increased morbidity and mortality from coronavirus disease 2019 (COVID‐19) in people with obesity have illuminated the intersection of obesity with impaired responses to infections. Although data on mechanisms by which COVID‐19 impacts health are being rapidly generated, there is a critical need to better understand the pulmonary, vascular, metabolic, and immunologic aspects that drive the increased...
Mounting evidence suggests that obesity, parameters of metabolic syndrome, and asthma are significantly associated. Interestingly, these conditions are also associated with microbiome dysbiosis, notably in the airway microbiome for patients with asthma and in the gut microbiome for patients with obesity and/or metabolic syndrome. Considering that improvements in asthma control, lung function, and...
Objective
Binge‐eating disorder (BED) disrupts dopamine neuron function, in part by altering dopamine transporter (DAT) activity. This study characterized the effects of high‐fat bingeing on presynaptic dopamine terminals and tested the hypothesis that acute low‐dose amphetamine would restore DAT function.
Methods
C57BL/6 mice were given limited access (LimA) to a high‐fat diet (2 h/d, 3 d/wk)...
Objective
This study aimed to evaluate the effects of an antenatal behavioral lifestyle intervention on total gestational weight gain (GWG) and perinatal outcomes.
Methods
Pregnant women with overweight and obesity in South Carolina were recruited into a theory‐based randomized controlled trial (n = 112 intervention, n = 105 standard care), which was designed to target weight self‐monitoring, increased...
Objective
This study aimed to determine the medical cost impact and return on investment (ROI) of a large, commercial, digital, weight‐management intensive lifestyle intervention (ILI) program (Real Appeal).
Methods
Participants in this program were compared with a control group matched by age, sex, geographic region, health risk, baseline medical costs, and chronic conditions. Medical costs were...
Objective
Little is known about the predictors of response to obesity interventions.
Methods
In 450 participants with obesity, body composition, resting energy expenditure, satiety, satiation, eating behavior, affect, and physical activity were measured by validated studies and questionnaires. These variables were used to classify obesity phenotypes. Subsequently, in a 12‐month, pragmatic, real‐world...
Researchers have speculated that vaccines to prevent coronavirus disease 2019 (COVID‐19) may be less effective for individuals with obesity, a major risk factor for mortality and morbidity from COVID‐19. Initial results from the Pfizer‐BioNTech and Moderna COVID‐19 vaccine trials, though limited by inadequate power to compare subgroups and incomplete stratification of high‐risk groups, appear to have...
Objective
Existing screening tools are inadequate in differentiating binge eating from normative overeating in treatment‐seeking individuals with overweight or obesity, as these individuals tend to overendorse loss‐of‐control (LOC; the hallmark characteristic of binge eating) on self‐report measures. In order for treatment centers to efficiently and accurately identify individuals who would benefit...
Objective
Experiments with animals suggest that high sugar consumption during pregnancy may predispose offspring to obesity, but few human studies have examined this relationship. This study explored the association between the consumption of sugar‐sweetened beverages (SSBs) during pregnancy and caloric intake through childhood.
Methods
Using cohort data on child weight, height, and physical activity...
Objective
In an ongoing effort to identify the genetic variation that contributes to obesity in American Indians, known Bardet–Biedl syndrome (BBS) genes were analyzed for an effect on BMI and leptin signaling.
Methods
Potentially deleterious variants (Combined Annotation Dependent Depletion score > 20) in BBS genes were identified in whole‐exome sequence data from 6,851 American Indians informative...
Objective
Loss‐of‐control (LOC) eating postoperatively is a consistent predictor of suboptimal longer‐term bariatric surgery outcomes. This randomized controlled trial examined the effectiveness of two guided self‐help treatments (cognitive behavioral therapy [gshCBT] and behavioral weight loss [gshBWL]) compared with a control (CON) for reducing LOC eating and weight.
Methods
A total of 140 patients...
Objectives
Self‐monitoring is critical for weight management, but little is known about lapses in the use of digital self‐monitoring. The objectives of this study were to examine whether lapses in self‐weighing and wearing activity trackers are associated with weight and activity outcomes and to identify objective predictors of lapses.
Methods
Participants (N = 160, BMI = 25.5 ± 3.3 kg/m2, 33.1...
Objective
This study examines BMI–mortality associations and evaluates strategies intended to limit reverse causality. Heterogeneity in BMI–mortality risk associations across subgroups and causes of death is explored.
Methods
A cohort of 654,382 adults from the US National Health Interview Survey was constructed. Associations between unit BMI levels and mortality were estimated using Cox proportional...
Objective
This study investigates the therapeutic potential of a small molecule inhibitor of plasminogen activator inhibitor‐1 (PAI‐1), TM5441, in reversing diet‐induced obesity in mice.
Methods
Wild‐type C57BL/6J mice were fed a high‐fat high‐sugar (HFHS) diet for 8 weeks to induce obesity. After the first 8 weeks, TM5441 was added to the diet for an additional 8 weeks. In order to determine the...
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